I-Anti- human CHI3L1 Antibody, i-Monoclonal yomuntu
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Chitinase-3-like protein 1 (CHI3L1) iyi-glycoprotein ebopha i-heparin eyimfihlo inkulumo yayo ehlotshaniswa nokufuduka kwe-vascular smooth muscle cell.I-CHI3L1 iboniswa emazingeni aphezulu kumasiko e-postconfluent nodular VSMC kanye namazinga aphansi kumasiko akhulayo angaphansi.I-CHI3L1 iyi-lectin ene-thishu, ebophezela i-chitin futhi iyilungu lomndeni we-glycosyl hydrolase 18. Ngokungafani nezinye izimpawu eziningi ze-monocyto / macrophage, ukuvezwa kwayo akukho kuma-monocyte futhi kunamandla phakathi nezigaba zamuva zokuhlukaniswa kwe-macrophage yomuntu.Amazinga aphezulu e-CHI3L1 ahlotshaniswa nokuphazamiseka okubonisa ukwanda kwezicubu ezixhumeneyo, njenge-rheum atoid, isifo samathambo, i-osteoarthritis, i-scleroderma, ne-cirrhosis yesibindi, kodwa kukhiqizwa ngoqwanga oluvela kubanikeli abadala noma iziguli ezine-osteoarthritis.I-CHI3L1 ivezwa ngendlela engavamile ku-hippocampus yezifundo ezine-schizophrenia futhi ingase ihileleke ekuphenduleni kwamaselula ezehlakalweni ezihlukahlukene zemvelo ezibikwa ukuthi zandisa ingozi ye-schizophrenia.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 2E4-2 ~ 1G11-14 13F3-1 ~ 1G11-14 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4 |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ukugcina isikhathi eside, sicela u-aliquot futhi ukugcine.Gwema imijikelezo yokuqanda nokuncibilika ephindaphindiwe. |
Ukuhlaziya Ukuqhathanisa
| I-bioantibody | icala elitholwe ngokomtholampilo | Ingqikithi | |
| positive | Okubi | ||
| positive | 46 | 3 | 49 |
| Okubi | 4 | 97 | 101 |
| Ingqikithi | 50 | 100 | 150 |
| inkomba yokuhlola | ukuzwela | ukucacisa | ukunemba |
| 92% | 97% | 95% | |
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-CHI3L1 | AB0031-1 | 1G11-14 |
| AB0031-2 | 2E4-2 | |
| AB0031-3 | 3A12-1 | |
| AB0031-4 | 13F3-1 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Kyrgios I , Galli-Tsinopoulou A , Stylianou C , et al.Amazinga aphakeme okujikeleza e-serum acute-phase protein YKL-40 (chitinase 3-like protein 1) awuphawu lokukhuluphala kanye nokungazweli kwe-insulin ezinganeni ngaphambi kokuthomba[J].I-Metabolism-clinical & Experimental, 2012, 61(4):562-568.
2.Yu-Huan M , Li-Ming T , Jian-Ying LI , et al.Ukuhlolwa kokusetshenziswa kwe-serum chitinase-3-like protein 1, alpha-fetoprotein kanye nokutholwa kwe-ferritin ekuxilongeni i-hepatocellular carcinoma[J].Imithi Yokuvimbela Okusebenzayo, 2018.
