Anti-human Her2 Antibody, Igundane Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Human epidermal growth factor receptor 2 (HER2), eyaziwa nangokuthi i-ErbB2, NEU, ne-CD340, iwuhlobo lwe-membrane ye-glycoprotein yohlobo lwe-I futhi iyingxenye yomndeni wamamukeli we-epidermal growth factor (EGF).Iphrotheni ye-HER2 ayikwazi ukubopha izici zokukhula ngenxa yokushoda kwesizinda esibophezelayo se-ligand esaso futhi esivinjelwe ngokuzenzakalelayo.Kodwa-ke, i-HER2 yakha i-heterodimer namanye amalungu omndeni we-EGF receptor eboshwe nge-ligand, ngakho-ke iqinisa ukubopha kwe-ligand futhi ithuthukise ukusebenza kwe-kinase-mediated kwama-molecule angezansi.I-HER2 idlala indima ebalulekile ekuthuthukisweni, ekwandeni kwamaseli nokuhlukanisa.I-HER2 gene kubikwe ukuthi ihlotshaniswa nesifo esiyingozi kanye nokungabikezeli kahle kwe-carcinoma eminingi, kuhlanganise nebele, i-prostate, i-ovary, umdlavuza wamaphaphu nokunye.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 14-2 ~ 15-6 15-6 ~ 2-10 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| Yena2 | AB0078-1 | 14-2 |
| AB0078-2 | 15-6 | |
| AB0078-3 | 2-10 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Krawczyk N, et al.(2009) Isimo se-HER2 kumaseli wesimila asatshalaliswa eziphikelelayo ngemva kokwelashwa kwe-adjuvant singahluka esimweni sokuqala se-HER2 kusimila esiyinhloko.I-Anticancer Res.29(10): 4019-24.
