Anti-human PLGF Antibody, Igundane Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Preeclampsia (PE) iyinkinga ebucayi yokukhulelwa ebonakala ngomfutho wegazi ophakeme kanye ne-proteinuria ngemva kwamasonto angu-20 okukhulelwa.I-Preeclampsia yenzeka ku-3-5 % wokukhulelwa futhi iphumela ekufeni komama noma kwengane noma kwezingane ezisanda kuzalwa kanye nokugula okukhulu.Ukubonakaliswa komtholampilo kungahluka kusuka kumafomu amancane kuya kwanzima;I-preeclampsia isengenye yezimbangela eziphambili zokugula nokufa kwengane kanye nomama.
I-Preeclampsia ibonakala ibangelwa ukukhululwa kwezici ze-angiogenic ku-placenta ezidala ukungasebenzi kahle kwe-endothelial.Amazinga e-serum e-PlGF (i-placental growth factor) ne-sFlt-1 (i-soluble fms-like tyrosine kinase‑1, eyaziwa nangokuthi i-soluble VEGF receptor‑1) ayashintshwa kwabesifazane abane-preeclampsia.Ngaphezu kwalokho, amazinga ajikelezayo e-PLGF kanye ne-sFlt-1 angabandlulula ukukhulelwa okuvamile ku-preeclampsia ngisho nangaphambi kokuba kuvele izimpawu zomtholampilo.Ekukhulelweni okuvamile, i-pro‑angiogenic factor PlGF iyanda phakathi nezinyanga ezimbili zokuqala futhi yehla njengoba ukukhulelwa kuqhubekela esikhathini.Ngokuphambene, amazinga e-anti-angiogenic factor sFlt‑1 ahlala ezinzile phakathi nezigaba zakuqala nezimaphakathi zokumitha futhi anda kancane kancane kuze kuphele isikhathi.Kwabesifazane ababa ne-preeclampsia, amazinga e-sFlt-1 atholakale engaphezulu futhi amazinga e-PlGF atholwe ephansi kunokukhulelwa okuvamile.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 7G1-2 ~ 5D9-3 5D9-3 ~ 7G1-2 |
| Ubumsulwa | >95% njengoba kunqunywa i-SDS-PAGE. |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-PLGF | AB0036-1 | 7G1-2 |
| AB0036-2 | 5D9-3 | |
| AB0036-3 | 5G7-1 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Brown MA, Lindheimer MD, de Swiet M, et al.Ukuhlukaniswa nokuxilongwa kwezinkinga ze-hypertensive zokukhulelwa: isitatimende esivela ku-International Society for the Study of Hypertension in Pregnancy (ISSHP).Ukukhulelwa kwe-Hypertens 2001;20(1):IX-XIV.
2.Uzan J, Carbonnel M, Piconne O, et al.I-Pre-eclampsia: i-pathophysiology, ukuxilongwa, nokuphathwa.I-Vasc Health Risk Manag 2011; 7:467-474.
