I-anti- human TIMP1 Antibody, Igundane i-Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-TIMP metallopeptidase inhibitor 1, eyaziwa nangokuthi i-TIMP-1/TIMP1, i-Collagenase inhibitor 16C8 fibroblast Umsebenzi we-Erythroid-potentiating, i-TPA-S1TPA-induced proteinI-Inhibitor ye-metalloproteinase 1, iyi-inhibitor yemvelo yeqembu le-MMP le-metalloproteinase ye-matrix ebandakanyeka ekulimazeni kwe-matrix engaphandle kweseli.I-TIMP-1/TIMP1 itholakala kuzicubu zengane nezabantu abadala.Amazinga aphezulu kakhulu atholakala emathanjeni, emaphashini, e-ovary nasesibelethweni.Ixubene nama-metalloproteinase futhi iwavale ngokungenakulungiseka ngokubopha ku-catalytic zinc cofactor yawo.I-TIMP-1/TIMP1 ilamula i-erythropoiesis in vitro;kodwa, ngokungafani ne-IL-3, iqondene nezinhlobo ezithile, ikhuthaza ukukhula nokuhlukaniswa kwama-progenitors e-erythroid abantu kanye ne-murine kuphela.Ngaphezu kwendima yayo yokuvimbela ngokumelene nama-MMP amaningi aziwayo, iphrotheni iyakwazi ukukhuthaza ukwanda kwamaseli ezinhlobonhlobo zezinhlobo zamaseli, futhi ingase ibe nomsebenzi wokulwa ne-apoptotic.Ukulotshwa kwalolu fuzo lombhalo wekhodi wephrotheni kuyathandeka kakhulu ekuphenduleni kuma-cytokines namahomoni amaningi.Ngaphezu kwalokho, inkulumo evela kwamanye ama-X chromosomes kodwa hhayi wonke angasebenzi iphakamisa ukuthi lokhu kungasebenzi kofuzo kuyi-polymorphic kwabesifazane abangabantu.Lolu fuzo lombhalo wekhodi lutholakala phakathi kwe-intron 6 yofuzo lwe-synapsin I futhi lubhalwe ngokuphambene.Iyinkimbinkimbi ngama-metalloproteinase futhi iwavale ngokungabuyiseleki ngokubopha ku-catalytic zinc cofactor yawo.I-TIMP-1/TIMP1 yaziwa ngokusebenza ku-MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 kanye I-MMP-16.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| Ubumsulwa | >95% njengoba kunqunywa i-SDS-PAGE. |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-TIMP1 | AB0034-1 | 1D5-5 |
| AB0034-2 | 1D12-2 | |
| AB0034-3 | 1G3-7 | |
| AB0034-4 | 3G11-6 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Barylski M , Kowalczyk E , Szadkowska I , et al.[I-tissue inhibitor ye-metalloproteinase[J].I-Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30(178):246-8.
2.Hayakawa T , Yamashita K , Tanzawa K , et al.Umsebenzi okhuthaza ukukhula we-tissue inhibitor ye-metalloproteinases-1 (TIMP-1) yohlu olubanzi lwamaseli Isici esisha sokukhula okungenzeka ku-serum[J].Izincwadi ze-FEBS, 1992, 298.
3.Haider DG , Karin S , Gerhard P , et al.I-Serum retinol-binding protein 4 yehliswa ngemva kokuncipha kwesisindo kubantu abakhuluphele ngokweqile.[J].Ijenali ye-Clinical Endocrinology & Metabolism (3): 1168-71.
