I-Anti-Human RBP4 Antibody, Igundane I-Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-retinol-binding protein 4 (RBP4) ingumthwali othize we-retinol (owaziwa nangokuthi uvithamini A), futhi unesibopho sokuguqulwa kwe-retinol engazinzile nengancibiliki esixazululweni samanzi ibe inkimbinkimbi ezinzile nencibilikayo ku-plasma ngokusebenzisana kwayo okuqinile.Njengelungu le-lipocalin superfamily, i-RBP4 equkethe isakhiwo se-β-barrel esinomgodi ochazwe kahle ikhishwa esibindini, bese ihambisa i-retinol kusuka ezitolo zesibindi kuya ezicutshini ze-peripheral.Ku-plasma, inkimbinkimbi ye-RBP4-retinol isebenzisana ne-transthyretin (TTR), futhi lokhu kubopha kubalulekile ekuvimbeleni ukuphuma kwe-RBP4 nge-glomeruli yezinso.I-RBP4 evezwe emthonjeni we-ectopic iletha kahle i-retinol emehlweni, futhi ukuntula kwayo kuthinta kakhulu ukubona ebusuku.Muva nje, i-RBP4 njenge-adipokine, itholakala ukuthi ivezwe kuzicubu ze-adipose futhi ihlotshaniswa nokukhuluphala, ukumelana ne-insulin (IR) kanye nohlobo lwe-2 yesifo sikashukela (T2DM).
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 9D11-8 ~ 3D4-1 3C8-1 ~ 3D4-1 |
| Ubumsulwa | >95% njengoba kunqunywa i-SDS-PAGE. |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-RBP4 | AB0032-1 | 9D11-8 |
| AB0032-2 | 3C8-1 | |
| AB0032-3 | 3D4-1 | |
| AB0032-4 | 1C6-1 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Aiwei YB , Vijayalakshmi V , Bodles AM , et al.I-retinol ebopha iphrotheni yesi-4 kubantu: ubudlelwano nokumelana ne-insulin, ukuvuvukala, kanye nokusabela ku-pioglitazone.[J].I-J Clin Endocrinol Metab(7):2590-2597.
2.Haider DG , Karin S , Gerhard P , et al.I-Serum retinol-binding protein 4 yehliswa ngemva kokuncipha kwesisindo kubantu abakhuluphele ngokweqile.[J].Ijenali ye-Clinical Endocrinology & Metabolism (3): 1168-71.
