Anti-human GH Antibody, Igundane Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-hormone yokukhula (GH) noma i-somatotropin, eyaziwa nangokuthi i-hormone yokukhula komuntu (hGH noma i-HGH), iyi-hormone ye-peptide ekhuthaza ukukhula, ukukhiqizwa kwamangqamuzana, kanye nokuvuselelwa kwamaseli kubantu nakwezinye izilwane.Ngakho ibalulekile ekuthuthukisweni komuntu.I-GH iphinde ikhuthaze ukukhiqizwa kwe-IGF-1 futhi ikhulise ukugxila kweglucose kanye nama-fatty acids mahhala.Iwuhlobo lwe-mitogen oluqondene kuphela nama-receptors ezinhlotsheni ezithile zamaseli.I-GH iyi-191-amino acid, i-polypeptide ye-single-chain ehlanganiswayo, igcinwe futhi ifihliwe ngamaseli e-somatotropic ngaphakathi kwamaphiko ahlangene we-anterior pituitary gland.
Ukuhlolwa kwe-GH kusetshenziselwa ukuxilonga ukuphazamiseka kwe-GH, okuhlanganisa:
★ ukuntuleka kwe-GH.Ezinganeni, i-GH ibalulekile ekukhuleni okujwayelekile nokuthuthuka.Ukuntuleka kwe-GH kungabangela ukuthi ingane ikhule kancane futhi ibe mfushane kakhulu kunezingane ezineminyaka efanayo.Kubantu abadala, ukuntuleka kwe-GH kungaholela ekunciphiseni kwamathambo nokunciphisa imisipha.
★ I-Gigantism.Lesi yisifo esingavamile sobuntwana esenza umzimba ukhiqize i-GH eningi kakhulu.Izingane ezine-gigantism zinde kakhulu ngokweminyaka yazo futhi zinezandla nezinyawo ezinkulu.
★ Acromegaly.Lokhu kuphazamiseka, okuthinta abantu abadala, kubangela ukuthi umzimba ukhiqize i-hormone yokukhula eningi kakhulu.Abantu abadala abane-acromegaly banamandla kunamathambo avamile futhi izandla ezikhulisiwe, izinyawo, nezici zobuso.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 7F5-2 ~ 8C7-10 |
| Ubumsulwa | / |
| Ukwakhiwa Kwesigcinalwazi | / |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| GH | AB0077-1 | 7F5-2 |
| AB0077-2 | 8C7-10 | |
| AB0077-3 | 2A4-1 | |
| AB0077-4 | 2E12-6 | |
| AB0077-5 | 6F11-8 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1. Ranabir S, Reetu K (Januwari 2011)."Ukucindezeleka nama-hormone".I-Indian Journal ye-Endocrinology kanye ne-Metabolism.15 (1): 18–22.doi:10.4103/2230-8210.77573.I-PMC 3079864. PMID 21584161.
2. Greenwood FC, Landon J (April 1966)."Ukukhula kwe-hormone secretion ekuphenduleni ukucindezeleka kumuntu".Imvelo.210 (5035): 540–1.Ibhakhodi:1966Natur.210..540G.doi:10.1038/210540a0.PMID 5960526. S2CID 1829264.
