Ulwazi oluvamile
I-Pepsinogen I, i-precursors ye-pepsin, ikhiqizwa yi-mucosa yesisu futhi ikhishwe ku-lumen yesisu kanye nokujikeleza kwe-peripheral.I-Pepsinogen iqukethe iketango elilodwa le-polypeptide lama-amino acid angama-375 anesilinganiso sesisindo samangqamuzana angama-42 kD.I-PG I (isoenzyme 1-5) ikhiqizwa ikakhulukazi amaseli ayinhloko ku-fundac mucosa, kuyilapho i-PG II (isoenzyme 6-7) ikhishwa yizindlala ze-pyloric kanye ne-proximal duodenal mucosa.
I-Precursor ibonisa izinombolo zamaseli angaphezulu kwesisu kanye namaseli ezindlala, futhi iqapha i-gastric atrophy ngokungaqondile.Baphinde bazinze ngendlela emangalisayo ngoba benza umsebenzi wabo ngaphansi kwezimo ezinzima ezikhona ohlelweni lokugaya ukudla.I-atrophy ye-corpus mucosa iholela ekuhlanganiseni okuphansi kwe-pepsinogen I futhi ngenxa yalokho ukukhululwa kwayo okuphansi ku-serum.I-Serum pepsinogen I ikhombisa ukusebenza nezimo ze-gastric mucosa.
Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 1C1-3 ~ 1G7-3 1E3-1 ~ 1G7-3 |
Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
Ukwakhiwa Kwesigcinalwazi | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4 |
Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
I-PGI | AB0005-1 | 1C1-3 |
AB0005-2 | 1E3-1 | |
AB0005-3 | 1G7-3 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
1.Sipponen P , Ranta P , Helske T , et al.Amazinga e-serum e-amidated gastrin-17 kanye ne-pepsinogen I ku-atrophic gastritis: ucwaningo lokulawula icala lokubuka.[J].I-Scandinavian Journal of Gastroenterology, 2002, 37(7):785-791.
2.Mangla JC , Schenk EA , Desbaillets L , et al.I-pepsin secretion, i-pepsinogen, ne-gastrin ku-esophagus ka-Barrett.Izici zomtholampilo kanye ne-morphological[J].I-Gastroenterology, i-1976, i-70 (5 PT.1): 669-676.