Anti- human IGFBP-1 Antibody, Igundane Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-IGFBP1, eyaziwa nangokuthi i-IGFBP-1 kanye ne-insulin-like growth factor-binding protein 1, iyilungu lomndeni wamaprotheni ohlanganisa i-insulin-like factor-binding.Amaprotheni abophezelayo e-IGF (IGFBPs) angamaprotheni angama-24 kuya ku-45 kDa.Wonke ama-IGFBP ayisithupha abelana nge-homology engu-50% futhi anezibopho ezibophezelayo ze-IGF-I ne-IGF-II ngendlela efanayo yobukhulu njengoba ama-ligand enawo we-IGF-IR.Amaprotheni abopha i-IGF andisa uhhafu wempilo yama-IGF futhi aboniswe ukuthi avimbela noma akhuthaze imithelela ekhuthaza ukukhula yama-IGF kusiko lamaseli.Bashintsha ukusebenzisana kwama-IGF nama-cell surface receptors awo.I-IGFBP1 inesizinda se-IGFBP kanye nesizinda se-thyroglobulin type-I.Ibopha zombili izici zokukhula ezifana ne-insulin (IGFs) I no-II futhi ijikeleze ku-plasma.Ukubophezelwa kwaleli phrotheni kwandisa uhhafu wempilo yama-IGF futhi kushintsha ukusebenzisana kwawo nama-cell surface receptors.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 4H6-2 ~ 4C2-3 4H6-2 ~ 2H11-1 |
| Ubumsulwa | >95% njengoba kunqunywa i-SDS-PAGE. |
| Ukwakhiwa Kwesigcinalwazi | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4 |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
| I-bioantibody | Icala Elihlonzwe Ngomtholampilo | Ingqikithi | |
| Okuhle | Okubi | ||
| Okuhle | 35 | 0 | 35 |
| Okubi | 1 | 87 | 88 |
| Ingqikithi | 36 | 87 | 123 |
| Ukucaciswa | 100% | ||
| Ukuzwela | 97% | ||
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-IGFBP-1 | AB0028-1 | 4H6-2 |
| AB0028-2 | 4C2-3 | |
| AB0028-3 | 2H11-1 | |
| AB0028-4 | 3G12-11 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Rutanen EM .Isici sokukhula esifana ne-insulin esibopha amaprotheni 1: US 1996.
2.Harman, S, Mitchell, et al.Amazinga eSerum e-Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, kanye ne-Prostate-Specific Antigen njengababikezeli beClinical Prostate Cancer[J].Ijenali ye-Clinical Endocrinology & Metabolism, 2000.
