Anti-human VEGF Antibody, Igundane Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Vascular endothelial growth factor (VEGF), eyaziwa nangokuthi i-vascular permeability factor (VPF) kanye ne-VEGF-A, ingumxhumanisi onamandla wakho kokubili i-angiogenesis kanye ne-vasculogenesis ku-fetus kanye nomuntu omdala.Iyilungu lomndeni we-platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) futhi ngokuvamile iba khona njenge-homodimer exhunywe yi-disulfide.Iphrotheni ye-VEGF-A iyi-mitogen ene-glycosylated esebenza ngokukhethekile kumaseli e-endothelial futhi inemiphumela ehlukahlukene, okuhlanganisa ukulamula ukwanda kokungena kwemithambo, ukunxenxa i-angiogenesis, i-vasculogenesis kanye nokukhula kwamaseli e-endothelial, ekhuthaza ukufuduka kwamaseli, ukuvimbela i-apoptosis nokukhula kwesimila.I-VEGF-A protein iphinde ibe yi-vasodilator eyandisa amandla e-microvascular permeability, ngakho-ke ekuqaleni yayibizwa ngokuthi yi-vascular permeability factor.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 12A4-7 ~ 5F6-2 2B4-6 ~ 5F6-2 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-VEGFA | AB0042-1 | 2B4-6 |
| AB0042-2 | 12A4-7 | |
| AB0042-3 | 5F6-2 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Tammela T , Enholm B , Alitalo K , et al.I-biology ye-vascular endothelial growth factor[J].Ucwaningo lwe-Cardiovascular, 2005, 65(3):550.
2.Wolfgang, Lieb, Radwan, et al.Isici sokukhula kwe-vascular endothelial, isamukeli sayo esincibilikayo, kanye nesici sokukhula kwe-hepatocyte: ukuhlobana komtholampilo kanye nofuzo kanye nokuhlotshaniswa nokusebenza kwemithambo.[J].Ijenali yenhliziyo yaseYurophu, 2009.
