I-IL6 ye-anti-human, i-Mouse Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Interleukin-6 (IL-6) iyi-cytokine ye-α-helical esebenzayo elawula ukukhula kwamangqamuzana nokuhlukaniswa kwezicubu ezihlukahlukene, eyaziwa ikakhulukazi ngendima yayo ekuphenduleni komzimba kanye nokusabela kwesigaba esibucayi.Iphrotheni ye-IL-6 ikhiqizwa izinhlobo ezahlukene zamaseli okuhlanganisa amaseli e-T nama-macrophage njenge-molecule ye-phosphorylated ne-glycosylated eguquguqukayo.Isebenzisa izenzo ngesamukeli sayo se-heterodimeric esakhiwe i-IL-6R engenaso isizinda se-tyrosine/kinase futhi ibophezela i-IL-6 ngokuhambisana okuphansi, futhi evezwa yonke indawo i-glycoprotein 130 (gp130) ebopha i-IL-6.I-IL-6R eyinkimbinkimbi enobudlelwane obuphezulu futhi ngaleyo ndlela idlulisa amasignali.I-IL-6 iphinde ihileleke ku-hematopoiesis, i-bone metabolism, kanye nokuqhubekela phambili komdlavuza, futhi ichazwe njengendima ebalulekile ekuqondiseni ukuguquka kusuka ekugomeni okuzelwe kuya kokutholwe.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 1B1-4 ~ 2E4-1 2E4-1 ~ 1B1-4 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Ukuhlaziya ukuhlobana-<120pg>
Ukuhlaziywa kokuhlobana -1.5-5000pg/mL
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-IL6 | AB0001-1 | 1B1-4 |
| AB0001-2 | 2E4-1 | |
| AB0001-3 | 2C3-1 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Zhong Z , Darnell ZW , Jr. Stat3: ilungu lomndeni le-STAT lenziwe lasebenza i-tyrosine phosphorylation ekuphenduleni ku-epidermal growth factor kanye ne-interleukin-6[J].Isayensi, 1994.
2.J, Bauer, F, et al.I-Interleukin-6 emithini yomtholampilo[J].I-Annals of Hematology, 1991.
