I-Anti-Flu A Antibody, Igundane I-Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
Umkhuhlane, noma umkhuhlane, isifo esithathelwanayo esibangelwa amagciwane omkhuhlane.Izimpawu zomkhuhlane zihlanganisa ubuhlungu bemisipha nobuhlungu, ikhanda elibuhlungu, nomkhuhlane.Igciwane lomkhuhlane wohlobo A lihlala lishintsha futhi ngokuvamile libangela ubhadane lomkhuhlane omkhulu.
Umkhuhlane A ungahlukaniswa ube yizinhlobo ezincane ezihlukene ngokusekelwe ekuhlanganisweni kwamaprotheni amabili endaweni yegciwane: i-hemagglutinin (H) ne-neuraminidase (N).
Izakhiwo
| Bhanqa Isincomo | IC(Ukuthwebula-Ukutholwa):1B5-6 ~ 3A9-8 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Yigcine ngaphansi kwezimo eziyinyumba ku -20℃kuye -80℃ekutholeni. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| Umkhuhlane A | AB0023-1 | 1F10-1 |
| AB0023-2 | 1B5-6 | |
| AB0023-3 | 3A9-8 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Senne DA , Panigrahy B , Kawaoka Y , et al.Inhlolovo yokulandelana kwesayithi ye-hemagglutinin (HA) ye-cleavage ye-H5 kanye ne-H7 yamagciwane omkhuhlane wezinyoni: ukulandelana kwe-amino acid endaweni ye-HA cleavage njengophawu lwamandla e-pathogenicity.[J].Izifo Zezinyoni, 1996, 40 (2): 425-437.
2.Benton DJ , Gamblin SJ , Rosenthal PB , et al.Ukuguqulwa kwesakhiwo kumkhuhlane we-hemagglutinin ku-membrane fusion pH[J].Imvelo, 2020:1-4.
3.1.Urai C, Wanpen C. Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy.Inkampani Biomed Res Int.2018.
4.2.UFlorian K. Ukusabela kwamasosha omzimba womuntu ekuthelelekeni ngegciwane lomkhuhlane A kanye nokugonywa.Imvelo ibuyekeza i-immunology.2019, 19, 383-397.
