Ulwazi oluvamile
I-hormone yocansi ebopha i-globulin (SHBG) iyi-glycoprotein engaba ngu-80-100 kDa;inobudlelwane obuphezulu be-17 beta-hydroxysteroid hormones njenge-testosterone ne-estradiol.I-SHBG
Ukugxila ku-plasma kulawulwa, phakathi kwezinye izinto, ibhalansi ye-androgen/estrogen, amahomoni egilo, i-insulin kanye nezici zokudla.Kuyiprotheni yokuthutha ebaluleke kakhulu yama-estrogens nama-androgens egazini le-peripheral.Ukugxila kwe-SHBG kuyisici esikhulu esilawula ukusatshalaliswa kwazo phakathi kwezifunda eziboshwe ngamaprotheni nezikhululekile.Ukugxila kwe-Plasma SHBG kukhona
ezithintekayo ngenani lezifo ezihlukahlukene, amanani aphezulu atholakala ku-hyperthyroidism, hypogonadism, ukungezwani kwe-androgen kanye ne-hepatic cirrhosis emadodeni.Ukugxila okuphansi kutholakala ku-myxoedema, hyperprolactinemia kanye nama-syndromes omsebenzi we-androgen oweqile.Ukukalwa kwe-SHBG kuyasiza ekuhloleni ukuphazamiseka okuncane kwe-androgen metabolism futhi kuvumela ukuhlonzwa kwalabo besifazane abane-hirsutism okungenzeka basabele ekwelashweni kwe-estrogen.
Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 3E10-1 ~ 3A10-5 3A10-5 ~ 3D8-2 |
Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
SHBG | AB0030-1 | 3A10-5 |
AB0030-2 | 3E10-1 | |
AB0030-3 | 3D8-2 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
1. I-Selby C. I-hormone yocansi ebopha i-globulin: imvelaphi, umsebenzi kanye nokubaluleka komtholampilo.U-Ann Clin Biochem 1990; 27:532-541.
2. Pugeat M, Crave JC, Tourniare J, et al.Isisetshenziswa somtholampilo se-sex hormone ebopha isilinganiso se-globulin.I-Horm Res 1996;45(3-5):148-155.