Anti-human MMP-3 Antibody, Igundane Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Matrix metallopeptidase 3 (efushanisiwe njenge-MMP3) yaziwa nangokuthi i-stromelysin 1 kanye ne-progelatinase.I-MMP3 iyilungu lomndeni we-matrix metalloproteinase (MMP) amalungu awo abambe iqhaza ekuqhekekeni kwe-matrix engaphandle kweseli ezinqubweni ezijwayelekile zomzimba, njengokuthuthukiswa kombungu, ukukhiqizwa kabusha, ukuguqulwa kwezicubu, nezinqubo zezifo ezihlanganisa isifo samathambo kanye ne-metastasis.Njenge-endopeptidase encike ku-zinc eyimfihlo, i-MMP3 yenza imisebenzi yayo ikakhulukazi ku-matrix engaphandle kwamaseli.Le phrotheni icushwe ama-endogenous inhibitors amabili amakhulu: i-alpha2-macroglobulin kanye nama-tissue inhibitors e-metalloproteases (TIMPs).I-MMP3 idlala indima ebalulekile ekwehliseni isithunzi izinhlobo ze-collagen II, III, IV, IX, no-X, i-proteoglycans, i-fibronectin, i-laminin, ne-elastin.Futhi, i-MMP3 ingasebenza amanye ama-MMP afana ne-MMP1, i-MMP7, ne-MMP9, okwenza i-MMP3 ibaluleke kakhulu ekwakhiweni kabusha kwezicubu ezixhumeneyo.I-Dysregulation ye-MMPs ifakwe ezifweni eziningi ezihlanganisa isifo samathambo, izilonda ezingapheli, i-encephalomyelitis, nomdlavuza.Ama-synthetic noma ama-inhibitor emvelo we-MMPs aphumela ekuvinjweni kwe-metastasis, kuyilapho ukulawulwa okuphezulu kwama-MMP kuholele ekuhlaselweni okuthuthukisiwe kwamaseli omdlavuza.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 11G11-6 ~ 8A3-9 11G11-6 ~ 5B9-4 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-MMP-3 | AB0025-1 | 11G11-6 |
| AB0025-2 | 8A3-9 | |
| AB0025-3 | 5B9-4 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Yamanaka H , Matsuda Y , Tanaka M , et al.I-Serum matrix metalloproteinase 3 njengesibikezelo sezinga lokubhujiswa kwamalunga phakathi nezinyanga eziyisithupha ngemva kokulinganisa, ezigulini ezinesifo samathambo sangaphambi kwesikhathi[J].I-Arthritis & Rheumatism, 2000, 43(4):852–858.
2.Hattori Y , Kida D , Kaneko A.Amazinga avamile e-serum matrix metalloproteinase-3 angasetshenziswa ukubikezela ukukhululwa komtholampilo kanye nokusebenza okuvamile komzimba ezigulini ezine-arthritis ye-rheumatoid[J].I-Clinical Rheumatology, 2018.
