I-anti-human GDF15 Antibody, Igundane I-Monoclonal
Imininingwane yomkhiqizo
Ulwazi oluvamile
I-Growth-differentiation factor 15 (GDF15), eyaziwa nangokuthi i-MIC-1, iyilungu eliyimfihlo le-transforming growth factor (TGF) -β superfamily, njengenoveli ye-antihypertrophic regulatory factor in the heart.I-GDF-15 / GDF15 ayivezwa enhliziyweni yomuntu omdala evamile kodwa yenziwa ngokuphendula izimo ezikhuthaza i-hypertrophy kanye ne-dilated cardiomyopathy futhi ivezwa kakhulu esibindini.I-GDF-15 / GDF15 ineqhaza ekulawuleni izindlela ezivuvukalayo kanye ne-apoptotic ezicutshini ezilimele nangesikhathi sezinqubo zesifo.I-GDF-15 / GDF15 ihlanganiswa njengama-molecule andulelayo acutshungulwa endaweni ye-dibasic cleavage ukuze kukhululwe izizinda ze-C-terminal eziqukethe i-motif yesici sama-cysteines alondoloziwe angu-7 kuphrotheni ekhulile.I-GDF-15 / GDF15 overexpression ephuma endaweni enwetshiwe ye-erythroid inomthelela ekulayishweni kwensimbi kuma-syndromes e-thalassemia ngokuvimbela isisho se-hepcidin.
Izakhiwo
| Bhanqa Isincomo | I-CLIA (Ukutholwa-Thatha): 23F1-5 ~ 6C1-9 23F1-5 ~ 3A2-1 |
| Ubumsulwa | >95%, kunqunywa i-SDS-PAGE |
| Ukwakhiwa Kwesigcinalwazi | I-PBS, pH7.4. |
| Isitoreji | Igcine ngaphansi kwezimo eziyinyumba ku -20℃ ukuya ku -80 ℃ uma yamukelwa. Ncoma ukuthi i-aliquot iphrotheni ibe ngamanani amancane ukuze uthole isitoreji esiphezulu. |
Ukuqhathanisa Ngokuncintisana
Oda Ulwazi
| Igama Lomkhiqizo | Ikati.Cha | I-Clone ID |
| I-GDF-15 | AB0038-1 | 3A2-1 |
| AB0038-2 | 23F1-5 | |
| AB0038-3 | 6C1-9 | |
| AB0038-4 | 4D5-8 |
Qaphela: I-Bioantibody ingakwazi ukwenza amanani ngendlela oyifisayo ngokwesidingo sakho.
Izingcaphuno
1.Wollert KC , Kempf T , Peter T , et al.I-Prognostic Value ye-Growth-Differentiation Factor-15 Ezigulini Ezingenayo I-ST-Elevation Acute Coronary Syndrome[J].Ukujikeleza, 2007, 115(8):962-971.
2.Kempf T, Haehling SV, Peter T, et al.Usizo olubikezelwayo lwesici sokuhlukanisa ukukhula-15 ezigulini ezinokwehluleka kwenhliziyo okungapheli.[J].Ijenali ye-American College of Cardiology, 2007, 50(11):1054-1060.
