Khuthaza Inqubo Yokuthuthukiswa Kwezidakamizwa
Ulwazi oluvamile
Iphothifoliyo ye-Bioantibody yokuqala esigabeni kanye nesezingeni eliphezulu iklanyelwe ukubhekana nezidingo ezibalulekile zezokwelapha ezingahlangatshezwanga ngokuthuthukiswa kwe-mono kanye ne-bi-specific protein therapy, ama-antibody conjugates ezidakamizwa kanye nama-macrophage stimulating agents ezigulini emhlabeni wonke.
Umlando
Ukutholwa kokuqala kobuchwepheshe be-monoclonal antibody (mAb) ngu-Kohler noMilstein ngo-1975 kunikeze ithuba lokudala amasosha omzimba njengekilasi lezokwelapha (Kohler & Milstein, 1975).Amasosha omzimba e-Monoclonal (mAbs) angenye yezindawo ezisetshenziswa kakhulu izidakamizwa zezifo ezithathelwanayo noma ukwelashwa komdlavuza ngoba zikhetha ngokukhetha amagciwane, amangqamuzana athathelwanayo, amangqamuzana anomdlavuza, kanye namaseli omzimba imbala.Ngale ndlela, balamula ukuqedwa kwama-molecule namaseli okuhlosiwe anemiphumela engemihle embalwa kunezinye izindlela zokwelapha.Ikakhulukazi, ama-mAbs okwelapha umdlavuza angabona amaprotheni angaphezulu kweseli kumaseli okuhlosiwe bese ebulala amaseli okuhlosiwe ngezindlela eziningi.
Ukwenziwa kobuntu kunciphisa kakhulu ukuzivikela kwe-antibody yokwelapha kubantu, okwenza ukuphatha okungapheli kwenzeke.Intuthuko enjalo kubuchwepheshe be-antibody ibangele ukuqhuma ekuthuthukisweni kwama-mAbs okwelapha kule minyaka eyishumi edlule.Uchungechunge lwama-antibody derivatives, oluhlanganisa amaprotheni e-Fc-fusion, ama-antibody-drug conjugates (ADCs), ama-immunocytokines (ama-antibody-cytokine fusions), kanye nokuhlanganisa ama-antibody-enzyme, nawo ayathuthukiswa futhi athengiswa njengokwelashwa okusha.
Imiphumela yezidakamizwa
Ezigulini, izidakamizwa ezintsha ezihlosiwe zisho imiphumela engemihle embalwa, ukulaliswa esibhedlela okumbalwa, izinga lempilo elithuthukisiwe, ukukhiqiza okukhulayo, futhi okubalulekile, ukuphila okunwetshiwe.Kodwa ukuthuthukiswa kwezidakamizwa kuyinqubo ende, eyinkimbinkimbi.
Ireferensi
U-Kohler G, uMilstein C. Amasiko aqhubekayo amaseli ahlanganisiwe akhiqiza i-antibody yokucaciswa okuchazwe ngaphambilini.Imvelo.1975;256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Imakethe yokwelapha ye-monoclonal antibody.MAbs.2015;7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics.I-Biosci Rep. 2015;35(4):e00225.Ishicilelwe ngo-2015 Jul 14. Itholakala ku-https://pubmed.ncbi.nlm.nih.gov/26182432/.Ifinyelelwe ngoJulayi 2020.
Reichert, JM, noValge-Archer, VE (2007).Amathrendi wokuthuthuka we-monoclonal antibody therapeutics.I-Nat Rev Drug Discov 6, 349-356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Izinhlobonhlobo ze-antibody Fc ezinjiniyela ezinomphumela othuthukisiwe.I-PNAS 103, 4005–4010.
